The expression must have been in popular use in the USA by 1894, when it was used in an advertisement as the name of a proprietary medicine for sore throats, in The Stevens Point Journal, November 1894:
"The Taylor Bros. say that 'Frog in the Throat' will cure hoarseness. 10 cents and box."
One theory about a frog in the throat is that the secretions of frogs helped cure sore throats. But that is just a theory, most likely not true but interesting to think about!
(source)
To say it today is to indicate that someone's voice has gone scratchy or rough.
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